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  • Title: Single-dose antimicrobial prophylaxis in open heart surgery.
    Author: Beam T, Raab T, Spooner J, Balderman S, Aldridge J, Bhayana J.
    Journal: Eur J Clin Microbiol; 1984 Dec; 3(6):598-604. PubMed ID: 6098476.
    Abstract:
    A single one-gram pre-operative dose of ceftriaxone was compared with seven one-gram doses of cefazolin administered peri-operatively with the aim of preventing infections associated with coronary artery bypass graft surgery. Ninety-four evaluable cases were analyzed; 49 patients received ceftriaxone and 45 received cefazolin. There was no significant difference in the number of infectious complications between the two groups. Ceftriaxone had a terminal half-life of approximately 15.7 hours. There was no toxicity associated with either antibiotic. Because of the reduced number of doses, single-dose prophylaxis may result in considerable savings. Single-dose prophylaxis with ceftriaxone was found to be an effective modality for prevention of infection in open heart surgery.
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