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  • Title: [Clinical and pharmacokinetic study of ceftriaxone in pediatric bacterial infections].
    Author: Meguro H, Nonaka C, Kawaoi T, Takahashi S, Fujii R, Arimasu O.
    Journal: Jpn J Antibiot; 1984 Nov; 37(11):2049-59. PubMed ID: 6098701.
    Abstract:
    Ceftriaxone (Ro 13-9904, CTRX) was evaluated for its safety and efficacy in 33 children with various bacterial infections including 10 cases of bacterial meningitis. CTRX was effective in all but 1 case who had acute mucositis due to a resistant strain of Enterobacter cloacae. The serum half-life (T1/2 beta) was 4.5 +/- 1.6 hours after an intravenous bolus injection in children. Cerebrospinal fluid levels of CTRX in the acute phase of bacterial meningitis were 7.69 +/- 4.75 mcg/ml. The only side effect was mild to moderate diarrhea observed in 10 of the 33 cases, but in no case was it necessary to discontinue the drug.
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