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  • Title: Inhibition via opioid mu- and delta-receptors of vagal transmission in rabbit isolated heart.
    Author: Weitzell R, Illes P, Starke K.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1984 Dec; 328(2):186-90. PubMed ID: 6098836.
    Abstract:
    The nervi vagi of isolated perfused rabbit hearts were stimulated by 10 s trains of electrical pulses at 1, 2 or 5 Hz. Morphine, Met-enkephalin and D-Ala2,D-Leu5-enkephalin reduced the ensuing bradycardia with IC50 values of 148, 25 and 3.2 nM, respectively. Naloxone antagonized the effects of morphine and Met-enkephalin; KB values (dissociation constants of antagonist-receptor complex) were 1.1 and 33 nM, respectively. The delta-receptor-selective antagonist ICI 174864 antagonized Met-enkephalin, KB 28 nM, but at 0.2 microM did not antagonize morphine. It is concluded that vagal transmission to the rabbit heart can be inhibited by activation of both opioid mu- und delta-receptors.
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