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  • Title: Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward.
    Author: Vaccarino FJ, Koob GF.
    Journal: Neurosci Lett; 1984 Nov 23; 52(1-2):61-6. PubMed ID: 6098878.
    Abstract:
    Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide (CCK-8S) into the nucleus accumbens were examined for effects on intracranial self-stimulation (ICSS) derived from the ventral tegmental area (VTA). The results showed that CCK-8S dose-dependently antagonized VTA intracranial self-stimulation (ICSS) without affecting maximum response rates. CCK-8S also increased the current threshold required for ICSS. These findings were interpreted to suggest that CCK-8S attenuates brain stimulation reward derived from the VTA.
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