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  • Title: Comparison of long term treatment of asthmatic children with hyposensitization, ACTH, DSCG and Ketotifen.
    Author: Osváth P, Endre L.
    Journal: Allergol Immunopathol (Madr); 1984; 12(6):471-7. PubMed ID: 6099051.
    Abstract:
    The authors treated 228 asthmatic children during a period of 3 years using a randomised scheme. After a short eliminatory trial the choice of preventive treatment was selected randomly using the patient's registration number. Four groups were formed: Hyposensitization, ACTH, DSCG and Ketotifen (Zaditen). Two thirds of the patients ameliorated in each group. According to the subjective opinion of the parents, 30-33% of the patients became symptomfree on each regimen. This figure was 50% in the hyposensitization and ACTH groups (13%). Serious asthma cases with more than 10 attacks in a year improved, mainly after DSCG or Ketotifen (Zaditen) therapy. The evaluation according to a symptom score and pulmonary function test shows definite amelioration in the groups chemoprophylactic drugs. After a change from the original therapy because of a failure, ACTH and Zaditen were the most successful second drug.
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