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  • Title: Herpes simplex virus genital infection of the female guinea pig as a model for the evaluation of an experimental vaccine.
    Author: Thornton B, Baskerville A, Bailey NE, Melling JM, Hambleton P.
    Journal: Vaccine; 1984 Jun; 2(2):141-8. PubMed ID: 6099646.
    Abstract:
    Substantial protection against herpes simplex type 2 (HSV 2) infection of the female guinea pig genital tract was provided by immunization with an experimental HSV 2 vaccine prepared from the plasma membranes of infected MRC-5 cells. Protection was evaluated in terms of the modification of histopathological lesions and clinical signs and in changes in viral replication and serological responses in vaccinated and control animals.
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