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  • Title: [Polish asbestos and its fibrogenic effect. I. Fibrous minerals in nickel ore deposits].
    Author: Woźniak H.
    Journal: Med Pr; 1984; 35(6):417-26. PubMed ID: 6100123.
    Abstract:
    In experiments on white rats (Wistar) fibrogenic effects of 6 samples of fibrous minerals collected at different levels of nickel ore deposits were investigated. Sample 1 contained exclusively anthophyllite, samples 2 and 3--anthophyllite and quartz (approx. 30%), sample 4 exclusively antigorite, sample 5-- antigorite and quartz (approx. 10%) and chamoisite. The test samples contained admixtures of ferrum (0.9-2%), nickel (0,07-0,2%), and copper (0,-0,05%). The average length of fibres was 6.2-12.5 micron. The fibrogenic effects of the test fibrous minerals did not differ from fibrogenic effects of crocidolite, chrystolite and quartz. The strongest fibrogenic effects were exhibited by the sample containing exclusively antigorite. Hydroxyproline content in lungs after 6 months' experiment amounted to over 8 mg on intratracheal administration of 25 mg of dust, whereas average lung weight--3650 mg. No clear dependence was found between free crystalline content in dust and dust fibrogenic effects.
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