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  • Title: Polypeptide activators of cholesterol side-chain cleavage.
    Author: Pedersen RC.
    Journal: Endocr Res; ; 10(3-4):533-61. PubMed ID: 6100256.
    Abstract:
    A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. This interaction is rapidly and reversibly sensitive to inhibitors of protein synthesis. For this reason a hormone-dependent, labile protein activator of cholesterol side-chain cleavage has long been postulated as an obligatory intermediate in the tropic regulation of this reaction. Applying recent advances in liquid chromatography, two-dimensional gel electrophoresis, and enzyme reconstitution into liposomes, several laboratories have now reported the isolation and partial characterization of polypeptide candidates for the status of "labile protein."
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