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  • Title: Evidence for the presence of fatty acid methyl esters in human hepatoma tissue from a patient with hypercholesterolemia.
    Author: Yoshida S, Tamura T, Tamura M, Takeshita M, Terao H, Fujioka T, Itoga T.
    Journal: J Appl Biochem; 1984; 6(5-6):314-8. PubMed ID: 6100292.
    Abstract:
    The lipid composition of a human hepatoma tissue (liver cell carcinoma) was examined by thin-layer chromatography (TLC), and an unusual lipid spot was found in a large quantity. It was identified as consisting of fatty acid methyl esters by TLC and gas chromatography-mass spectrometry techniques. In the fatty acid methyl ester fraction, oleate (18:1) and palmitate (16:0) were dominant. Furthermore, very unusual fatty acid methyl esters, such as methyl 2-methyl oleate, were detected. These unusual lipids could be detected neither in cirrhotic lesions of the host liver nor in normal control tissues.
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