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  • Title: Elimination kinetics of ceftizoxime in humans with and without renal insufficiency.
    Author: Ohkawa M, Okasho A, Sugata T, Kuroda K.
    Journal: Antimicrob Agents Chemother; 1982 Aug; 22(2):308-11. PubMed ID: 6100425.
    Abstract:
    The pharmacokinetics of a single 500-mg intramuscular dose of ceftizoxime were studied in 11 healthy adult volunteers and in 22 patients with various degrees of renal dysfunction. The mean serum half-life of ceftizoxime was 1.44 h in normal subjects and 30.2 h in hemodialysis patients. A significant correlation (P less than 0.001) between the elimination rate constant of ceftizoxime and creatinine clearance was demonstrated. The mean urinary recovery in normal subjects was 75.6% within 6 h of dosage; recovery decreased progressively with reduced renal function.
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