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  • Title: Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.
    Author: Gillin FD, Reiner DS, Suffness M.
    Journal: Antimicrob Agents Chemother; 1982 Aug; 22(2):342-5. PubMed ID: 6100431.
    Abstract:
    Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.
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