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  • Title: Effect of desamino-cholecystokinin-octapeptide (CCK-7) on the intraluminal pressure and myoelectrical activity of the gall-bladder, stomach, and small intestine in conscious dogs.
    Author: Milenov E, Nieber K, Niedrich H, Oehme P, Vogt WE.
    Journal: Br J Pharmacol; 1983 Dec; 80(4):681-9. PubMed ID: 6100845.
    Abstract:
    Desamino-cholecystokinin-octapeptide (CCK-7) increased the gall-bladder pressure and decreased the gastric pressure following i.v. infusion in conscious dogs. In small intestine and Heidenhain pouch CCK-7 exerted an initial excitatory effect followed by an inhibitory effect on intraluminal pressure and peristalsis. In all organs the effect of CCK-7 on pressure was correlated with a change of spike discharge. CCK-7 is more potent on gastrointestinal motor activity than a Boots preparation of pancreozymin. The results suggest that CCK-7 at doses within the physiological range could be involved in the regulation of gastrointestinal motility.
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