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  • Title: Effect of exogenous fatty acids on growth, membrane fluidity, and phospholipid fatty acid composition in yeast.
    Author: Esfahani M, Kucirka EM, Timmons FX, Tyagi S, Lord AE, Henry SA.
    Journal: J Supramol Struct Cell Biochem; 1981; 15(2):119-28. PubMed ID: 6100953.
    Abstract:
    The growth response of a double-mutant fatty acid auxotroph of yeast Saccharomyces cerevisiae to exogenous saturated fatty acids of a homologous series from 12:0 to 16:0, each supplied with oleate, linoleate, linolenate, or cis-delta 11-eicosenoate, cannot be explained in terms of the efficiency of incorporation of the fatty acids into phospholipids or alteration of membrane fluidity. There is, however, a negative correlation between growth and levels of 12:0 plus 13:0 in phospholipids, as well as a positive correlation between growth and levels of 14:0, 15:0, and 16:0. We, therefore, conclude that the predominant factor in these phospholipid fatty acyl chain modifications is maintenance of an optimal concentration of C14:0 through C16:0 in phospholipids of this organism.
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