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  • Title: [Elimination of allogeneic inhibition of hematopoietic stem cells by treatment of the recipient mice with cyclophosphane].
    Author: Golovistikov IN.
    Journal: Biull Eksp Biol Med; 1976; 81(4):447-9. PubMed ID: 6101.
    Abstract:
    The experiments demonstrated that pretreatment of lethally irradiated recipient (CBA X C57BL/6) F1hybrid mice with cyclophosphamide (200 mg/kg of body weight) on day before the bone marrow transplantation (4 hours after the irradiation) suppressed the allogeneic inhibition of hematopoietic stem cells to 24% (while the inhibition in the untreated animals was 92.5%). It is suggested that cyclophosphamide acted on the recipient's radioresistant lymphoid cells effecting the allogeneic inhibition of stem cells.
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