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  • Title: [Peripheral regulation of the adrenergic mediator process in the smooth muscles of the rat small intestine].
    Author: Putintseva TG, Turpaev TM, Selivanova GP.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1980 Feb; 66(2):249-55. PubMed ID: 6102529.
    Abstract:
    Under the effect of noradrenaline a physiologically active substance (A-factor) is released from smooth fibres of rat's intestine. A-factor enhances spontaneous activity of an isolated piece of rat's intestine. The A-factor is thermostable, its stimulating action is blocked neither with alpha- nor with beta-adrenolytics which indicates a non-catecholamine nature of this substance. Blocking of the intramural nervous system with novocain does not stop the release of the A-factor which shows that this system is not responsible for the A-factor release. Metabolic adrenoreceptors rather than the functional ones are responsible for the release of this substance. Experiments with metabolic poisons (2,4-dinitrophenol) and sodium fluoride have shown that the release of the A-factor is due to the effect of noradrenaline on glycolysis. The A-factor increases sensitivity of the intestine piece to noradrenaline. Participation of the A-factor in the regulation of the activity of smooth muscle adrenoreceptors of rat's intestine on the principle of positive feedback, is discussed.
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