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  • Title: [Effect of chromium ions on the function of neuromuscular junctions].
    Author: Zefirov AL, Poletaev GI, Gusel'nikova GG.
    Journal: Biofizika; 1980; 25(1):115-9. PubMed ID: 6102871.
    Abstract:
    It has been shown on neuro-muscular preparations of frog sartorius muscle that chromium ions in the concentrations 1-4 x 10(-6) g/ml strengthen spontaneous and evoked transmitter release. Cr3+ ions in the concentrations above 4 x 10(-6) g/ml decrease the membrane potential of muscle fibres, decrease the quantum content of the end plate potentials. Experiments on a single Ranvier node have shown that Cr3+ ions decrease the amplitude, increase the rate and duration of the action potential of a nerve fibre. It is concluded that chromium ions produce a pronounced effect on synaptic transmission, which differs significantly from the action of manganese, cobalt and nickel ions.
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