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  • Title: Hageman factor deficiency and oral contraceptives.
    Author: Mangal AK, Naiman SC.
    Journal: Lancet; 1980 Apr 05; 1(8171):774. PubMed ID: 6103195.
    Abstract:
    Hageman factor, a coagulation factor (Factor 12) is reported to be deficient in users of OCs (oral contraceptives) in this letter to the editor. A 21-year-old female on OCs for 4 months was admitted with sudden onset of chest pain and shortness of breath; a lung scan confirmed bilateral pulmonary embolism. She underwent a coagulation screen, prior to heparin therapy, which revealed a partial thromboplastin time of 120 seconds. A 15% Hageman factor deficiency was found. It is suggested that before prescribing OCs, physicians should screen patients by partial thromboplastin time, at the least, to determine if Hageman factor is deficient.
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