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  • Title: [Hormonal modulation of inflammation].
    Author: Bussolino F, Camussi G, Ragni R, Masera C, Rotunno M, Vercellone A.
    Journal: Minerva Med; 1980 Mar 24; 71(11):835-40. PubMed ID: 6103522.
    Abstract:
    The tissue damage during the inflammation is determined by the enzymes and the mediators of anaphylaxis released from polymorphonuclear cells (PMN), platelets, basophils and mastocytes. The control of this release involves the cAMP and cGMP. The cyclic nucleotides independently or synergically regulate the polymerisation of the microtubules and the microfilaments. Drugs increasing the intracellular concentration of cAMP or cGMP inhibit or enhance respectively the enzymatic release from PMN, basophils and mastocytes. In the platelets, cAMP plays a very important role, whereas the cGMP function is controversial.
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