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  • Title: Absence of effect of somatostatin on the guinea pig gallbladder.
    Author: Poitras P, Yamada T, Walsh JH.
    Journal: Can J Physiol Pharmacol; 1980 Feb; 58(2):179-82. PubMed ID: 6103746.
    Abstract:
    The effect of somatostatin (GH-RIH) on cholecystokinin octapeptide (OP-CCK) or acetylcholine (ACh) induced contraction of the guinea pig gallbladder was evaluated in vitro. GH-RIH failed to inhibit the muscle contraction induced by OP-CCK or ACh. To correlate with the in vitro results, the effect of GH-RIH on OP-CCK induced contraction of the gallbladder was evaluated in the guinea pig in vivo. GH-RIH did not affect the OP-CCK induced contraction of the gallbladder. Our results suggest that GH-RIH does not have direct inhibitory effect on the contraction of the guinea pig gallbladder induced by OP-CCK or ACh.
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