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  • Title: Antagonist/agonist-preferring alpha-adrenoceptors or alpha 1/alpha 2-adrenoceptors?
    Author: Tanaka T, Starke K.
    Journal: Eur J Pharmacol; 1980 May 02; 63(2-3):191-4. PubMed ID: 6103816.
    Abstract:
    Yohimbine and some stereoisomeric alkaloids inhibited the binding of 3H-clonidine and 3H-WB-4101 to rat cerebral cortex membranes. Rauwolscine and yohimbine had much higher affinity to the 3H-clonidine than to the 3H-WB-4101 site, whereas the reverse was true for corynanthine. The results indicate that the 3H-clonidine site is an alpha 2-adrenoceptor and not an agonist-selective site whereas the 3H-WB-4101 site is an alpha 1-andrenoceptor and not an antagonist-selective site.
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