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  • Title: Identification of leukotriene C-1 as a major component of slow-reacting substance from rat mononuclear cells.
    Author: Bach MK, Brashler JR, Hammarström S, Samuelsson B.
    Journal: J Immunol; 1980 Jul; 125(1):115-7. PubMed ID: 6103909.
    Abstract:
    Slow-reacting substance (SRS) was produced by rat peritoneal mononuclear cells after stimulation with the ionophore A23187. The SRS consisted of two main components as judged by high-pressure liquid chromatography (HPLC) on Florisil. The larger and more polar component consisted mainly of leukotriene (LT) C-1 as judged by ultraviolet spectroscopy, mass spectrometry (after desulfurization), amino acid analysis, and conversion by soybean lipoxygenase. Comparisons with authentic LTC-1 showed identity on reverse phase HPLC and guinea pig ileum bioassay. The latter methods are known to distinguish between LTC-1 and stereoisomers of LTC-1.
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