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  • Title: In vitro actions of ranitidine, a new histamine H2-receptor antagonist.
    Author: Daly MJ, Stables R.
    Journal: Agents Actions; 1980 Apr; 10(1 Pt 2):190-1. PubMed ID: 6104417.
    Abstract:
    Ranitidine has been tested on isolated guinea-pig right atrium and rat uterine horn, tissues known to possess histamine H2-receptors; and on isolated guinea-pig ileum a tissue containing histamine H1-receptors. These experiments have shown ranitidine to be a potent competitive antagonist of histamine at H2-receptor sites in vitro. This action is selective since high concentrations of ranitidine do not affect beta-adrenoceptor, histamine H1-receptor and muscarinic receptor mediated responses.
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