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  • Title: Association of guanylate cyclase with the axoneme of retinal rods.
    Author: Fleischman D, Denisevich M, Raveed D, Pannbacker RG.
    Journal: Biochim Biophys Acta; 1980 Jun 19; 630(2):176-86. PubMed ID: 6104515.
    Abstract:
    Axonemes were isolated from purified bovine retinal rod outer segments by dissolving the outer segment membranes in detergent and separating the axonemes by centrifugation on a linear detergent-containing sucrose density gradient. Guanylate cyclase (GTP pyrophosphate-lyase (cyclizing), EC 4.61.2) activity was concentrated in the axoneme fraction. Guanylate cyclase eluted in the void volume when detergent-solubilized rod outer segments were subjected to exclusion chromatography on Sepharose 4B. Attempts to extract guanylate cyclase from isolated axonemes with salt, EDTA, base and other reagents were successful.
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