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  • Title: Leukotriene C5: a slow reacting substance derived from eicosapentaenoic acid.
    Author: Hammarström S.
    Journal: J Biol Chem; 1980 Aug 10; 255(15):7093-4. PubMed ID: 6104669.
    Abstract:
    Mouse mastocytoma cells incubated with ionophore A23187 and eicosapentaenoic acid (n-3) produced a slow reacting substance with different properties compared with leukotriene C4 (previously designated leukotriene C). This product was characterized by spectroscopy and enzymatic and chemical degradations to be 5-hydroxy-6-S-glutathionyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene C5). Leukotriene C5 has similar biological activity on the isolated guinea pig ileum but is less potent than is leukotriene C4.
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