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  • Title: [Effect of a fixed betablocker diuretic combination in hypertension compared with the effect of the single components (author's transl)].
    Author: Burghuber F, Fiala W, Freitag A, Krötlinger M, Pflegerl W, Rainer P, Tönies H, Tutsch G, Winkler E.
    Journal: Wien Med Wochenschr; 1980 Mar 31; 130(6):222-6. PubMed ID: 6104874.
    Abstract:
    In a double blind designed treatment trial with three randomized groups of patients the effect of a fixed betablocker diuretic combination (Torrat, Boehringer Mannheim GmbH) was compared with the effect of the single components. 66 patients with essential and renal hypertension stage I and II according to the WHO definition were evaluated. 27 patients were treated with 1 tablet, 32 with 2 X 1 tablet, and 7 patients with 3 X 1 tablet daily. Besides of the blood pressure lowering effect over an observation period of 10 weeks the influence on pulse rate, potassium, blood sugar and uric acid were investigated. It could be shown that the blood pressure lowering effect was highest under the combination-drug. The treatment with the single components showed a less pronounced influence on the blood pressure, thus hinting at an additive effect of the 2 components metipranolol and butizide when given together. The combination exerts few side effects and does not influence the investigated parameters of metabolism over a longer period of time.
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