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  • Title: [Hydroxylation of the aromatic nuclei and heterocyclic ring of the fenazepam molecule in the endoplasmic reticulum of white rats and mice].
    Author: Meteshkin IuV, Golovenko NIa, Bogatskiĭ AV, Zin'kovskiĭ VG, Iavorskiĭ AS.
    Journal: Biull Eksp Biol Med; 1980 Jun; 89(6):700-2. PubMed ID: 6104998.
    Abstract:
    The reactions of 14C- and 3H-phenazepam hydroxylation by liver microsomes of mice and rats were examined to detect the formation of 3-hydroxymetabolite and products of aromatic hydroxylation of phenazepam molecule. The kinetics of the appearance of these products was studied. It was established that enzyme complex of mouse microsomes rather produced 3C-hydroxylation of the drug, while microsomes of rats produced reactions of hydroxylation of phenazepam aromatic rings.
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