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  • Title: Peculiarities of the virus-host cell relationship in a calf kidney cell line persistently infected with measles virus.
    Author: Sorodoc I, Aderca I, Cajal N, Dumitrescu SM, Constantinescu O, Cernescu C.
    Journal: Acta Virol; 1980 Jun; 24(4):253-64. PubMed ID: 6106376.
    Abstract:
    Persistent infection with measles virus established in a calf kidney cell line differed in some features from other measles virus carrier systems. After a variable life span, ranging from 50 to 1100 days, six of the chronically infected cell lines showed an evolution towards lytic infection. Only one of these lines, the K-2 cell line, exhibited marked morphological, growth and chromosomal alterations suggesting in vitro cellular transformation. The transformed K-2 cells released infectious measles virus with several modified biological parameters. Persistent infection was not due to the accumulation of thermosensitive mutants or defective particles. The role of the host-cell factor and of the selection of the virus population during its passage in RV cells are discussed.
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