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  • Title: [Low diuretic dosage in a beta blocker-diuretic combination].
    Author: Liewald HJ, Schrey A, Grund R.
    Journal: Med Klin; 1980 Aug 29; 75(18):654-7. PubMed ID: 6106884.
    Abstract:
    Thirty outpatients with arterial hypertension were treated for eight weeks with a daily dose of one tablet of Cardiotensin, taken after breakfast. The compound contains 100mg bupranolol, 10mg bemetizide and 20mg triamterene. Drug therapy was preceded by a one-week placebo washout period. Within two weeks of treatment, systolic and diastolic blood pressure had reverted to normal in 26 of the patients. At the end of the observation period, 4 patients still had diastolic pressure values of more than 100 mm Hg. Ergometer stress testing revealed clear-cut diminution of blood pressure and heart rate elevations following the medication. Serum potassium levels were not influenced by the drug. Under the mentioned dose regimen there were no changes in serum uric acid, creatinine, and glucose concentrations. Tolerability was generally good.
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