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  • Title: Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
    Author: Pearson D, Shively JE, Clark BR, Geschwind II, Barkley M, Nishioka RS, Bern HA.
    Journal: Proc Natl Acad Sci U S A; 1980 Aug; 77(8):5021-4. PubMed ID: 6107911.
    Abstract:
    Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.
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