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  • Title: In-vitro and in-vivo effects of theophylline and beta 2-adrenostimulants in combination.
    Author: Svedmyr N, Svedmyr K.
    Journal: Eur J Respir Dis Suppl; 1980; 109():83-91. PubMed ID: 6108228.
    Abstract:
    In-vitro studies on human bronchial and skeletal muscle indicate that a combination of theophylline and adrenergic beta 2-stimulants might give a potentiated therapeutic effect with fewer side effects, such as tremor, than treatment with beta 2-stimulants alone. In-vivo studies in asthmatics showed that pretreatment with oral bronchodilating doses of theophylline and terbutaline potentiated the effect of terbutaline given by inhalation. Oral doses of theophylline or a beta 2-adrenostimulant combined with beta 2-stimulants by aerosol therefore seem to be an effective form of treatment. The choice of oral treatment depends on the side effects. Theophylline in slow-release formulation might have advantages over oral beta 2-stimulants in children and young adult asthmatics. In patients with tremor problems, theophylline would also appear preferable: a combination of low oral doses of theophylline and beta 2-adrenostimulants have better bronchodilation with less skeletal muscle tremor than a higher dose of beta 2-adrenostimulants by mouth alone and perhaps have advantages in elderly asthmatics.
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