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  • Title: [Effect of the antihistamine preparation, phencarol, on the central nervous system].
    Author: Kaminka ME, Roshchina LF, Mashkovskiĭ MD.
    Journal: Farmakol Toksikol; 1980; 43(2):148-53. PubMed ID: 6108233.
    Abstract:
    The new antihistaminic and antiallergic drug phencarol (quinuclidy-3-diphenylcarbinol hydrochloride) in contradistinction to dimedrol (diphenhydramine) and diprazine (promethazin) exerts no pronounced depressant effect on the central nervous system. It does not significantly influence the period of action of hypnotic drugs, the effects produced by alcohol, spontaneous motor activity, summation capacity of the central nervous system, conditioned reflexes or electroencephalogram. That phencarol possesses no marked central action may be accounted for by its low lipophilic activity and little permeability of the blood brain barrier by this drug.
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