These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Age-related alterations in the cardiovascular response to adrenergic mediated stress.
    Author: Lakatta EG.
    Journal: Fed Proc; 1980 Dec; 39(14):3173-7. PubMed ID: 6108242.
    Abstract:
    Cardiovascular adaptation to stress is highly dependent on adrenergic stimulation. It may be hypothesized that the diminished cardiovascular response to acute stress that occurs in advanced age may result in part from an age-related decrease in the effectiveness of adrenergic stimulation. Studies employing beta-adrenergic agonists and antagonists in both man and animals provide support for this hypothesis. In addition, a postsynaptic decrement in sympathetic responsiveness is indicated from in vitro studies in both cardiac and vascular tissue. However, while a strong case for diminished adrenergic responsiveness of the aged cardiovascular system can be made from these data, further information at both the tissue and the organismal level is required to fully elucidate the nature of this age-related decline.
    [Abstract] [Full Text] [Related] [New Search]