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  • Title: [Suppression, by beta-adrenergic receptor blockade, of the sympathomimetic component of dopamine renal action in water-saline depletion].
    Author: Agnoli GC, Cacciari M, Garutti C, Lenzi P.
    Journal: Boll Soc Ital Biol Sper; 1980 May 15; 56(9):946-52. PubMed ID: 6108775.
    Abstract:
    The effects of beta-adrenergic receptor blockade on the renal action of Dopamine (DA) in hydro-saline depletion were investigated in 9 healthy subjects. The beta-adrenergic blocking treatment was performed (Propranolol hydrochloride 2.4 mg/kg b.w. per day) during the 2 days preceding the renal function studies. For other experimental details, see our previous Note (11). In the presence of beta-adrenergic blockade DA effects in hydro-saline depletion consisted of: a) an increase in both RPF and GFR; b) a decrease in sodium abnormally isoosmotic reabsorption as % of sodium distal load; c) an increase in both sodium and osmolar clearances; d) an increase in free water clearance higher than that observed in the absence of blocking treatment. Therefore, the sympathomimetic effects of DA in hydro-saline depletion appear to be suppressed by beta-adrenergic blockade. It is suggested that such sympathomimetic action of DA may be mediated by beta-presynaptic receptors of noradrenergic nerve endings.
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