These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Imidazole H2-antagonists and H2-angonists: effects of 5-alkyl substitution].
    Author: Vitali T, Impicciatore M, Ferrari C, Morini G.
    Journal: Farmaco Sci; 1980 May; 35(5):366-79. PubMed ID: 6108872.
    Abstract:
    The effects of some imidazole derivatives, H2-antagonists and H2-agonists, with different alkyl groups in 5-position (R = Me, Et, i.Pr), were studied comparatively on cat gastric secretion and guinea-pig gastric fundus. The antagonistic and agonistic activities decrease with increase in the substituent inductive effect, and, in particular, it should be noted that the cimetidine ethyl analog (compound V) is a competitive antagonist of H2-histamine receptors. More hypotheses on the H1- and H2-receptor surfaces are proposed.
    [Abstract] [Full Text] [Related] [New Search]