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  • Title: Sites of paradoxical action of the LHRH agonist (D-Trp6)-LHRH.
    Author: Arimura A, Talbot S, Serafini PC, Schally AV.
    Journal: Int J Fertil; 1980; 25(3):151-6. PubMed ID: 6108923.
    Abstract:
    Immature intact and hypophysectomized female rats, which were primed with gonadotropin, were injected subcutaneously with 0.9% saline or 0.2 or 2 microgram of (D-Trp6)-LHRH once daily for 7 days. Ovarian LH/hCG receptors and ovarian weight were measured 24 hours after the last analog or saline injection. A significant reduction (P < 0.01) of ovarian LH/hCG receptors in both intact and hypophysectomized rats was observed following administration of (D-Trp6)-LHRH in doses as low as 0.2 microgram/day. A significant decrease was observed in the ovarian weight of 2 microgram-treated rats (P < 0.05). The dramatic loss of ovarian LH/hCG receptors in hypophysectomized rats induced by (D-Trp6)-LHRH may indicate that the analog has a direct effect on the ovaries.
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