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  • Title: LH-RH therapy in functional amenorrhea based on clinical subclassification.
    Author: Hanker JP, Bohnet HG, Doz P, Leyendecker G, Schneider HP.
    Journal: Int J Fertil; 1980; 25(3):222-33. PubMed ID: 6108933.
    Abstract:
    The diagnostic approach to functional amenorrhea comprising a gestagen test, an LH-RH test, and the response to clomiphene as well as the recording of endogenous LH episodes allows a subclassification of the patients with regard to different therapeutic approaches. According to the degree of endogenous LH-RH deficiency, which is reflected by this diagnostic workup, a therapy with clomiphene alone, LH-RH combined with clomiphene, or LH-RH alone is effective. To avoid paradoxical effects any LH-RH substitution has to meet physiological conditions. Thus pulsatile and low-dose LH-RH administration of varied duration proved able to prime the hypothalamo-pituitary unit for either clomiphene or gonadal feedback signals resulting in ovulation and corpus luteum formation.
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