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  • Title: [Determination of alanine aminopeptidase and lactate dehydrogenase in the urine as a control over the patient's course after kidney transplantation].
    Author: Nagel HR, Templin R, Pietruschka U, Schneider KP, Dummler W, Erdmann T.
    Journal: Z Urol Nephrol; 1980 Oct; 73(10):747-57. PubMed ID: 6109414.
    Abstract:
    In 42 patients the determination of alanine aminopeptidase and lactate dehydrogenase in the urine was performed after transplantation of a kidney. In the evaluation of the enzyme activities it was referred to the clinically made rejection diagnosis as well as to the increase of the serum creatinine. We found out that with regard to the clinically made rejection diagnosis the alanine aminopeptidase in 56% and the lactate dehydrogenase in 55% of the cases showed an increase before the beginning of the rejection therapy. Before the corresponding increase of the serum creatinine we could establish an increase of the enzyme activity in the alanine aminopeptidase in 45% and in the lactate dehydrogenase in 65% of the cases. For a better interpretation of the urinary enzyme activities during the rejection crises the average activities of the enzymes immediately after the dismissal of the patients as well as three months, six months and one year after the transplantation are cited. From our investigation results that the daily determination of alanine aminopeptidase and lactate dehydrogenase in the urine is suited, taking into consideration other possible influence factors on the enzyme activity as well as other parameters, to support the diagnostics in finding the rejection after the transplantation of a kidney.
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