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  • Title: [Effect of different FiO2 on the ventilatory action of almitrine in the anesthetized dog. Preliminary study].
    Author: Gaudy JH, Dauthier C, Férracci F, Boitier JF.
    Journal: Ann Anesthesiol Fr; 1980; 21(2):145-7. PubMed ID: 6109490.
    Abstract:
    The effects of progressively increasing hyperoxia from 0.22 to 1 on the ventilatory action of a ventilatory analeptic with a peripheral action, almitrine, were studied in six dogs under deep anaesthesia by Alfatesine administered at a constant flow rate. At FiO2 = o.22, almitrine partially corrected hypoventilation. From FiO2 o.30 to FiO2 0.50, initial hypoventilation was unaltered. At FiO2 = 1, it was worsened. This preliminary study will need to be completed by examination of the interference almitrine-FiO2 at different levels of anaesthesia and of respiratory depression, by study of the effects of different levels of FiO2 on the respiratory depression caused by Alfatesine and by study of the effects of the sudden administration of pure oxygen.
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