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  • Title: Biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl in the rat.
    Author: Hanzlik RP, Bhatia P, Stitt R, Traiger GJ.
    Journal: Drug Metab Dispos; 1980; 8(6):428-33. PubMed ID: 6109612.
    Abstract:
    The biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl (MMT) has been studied in vivo in the rat, and in vitro by using rat liver and lung microsomes. Orally administered 3H-MMT is efficiently absorbed, metabolized, and excreted in the urine as two major metabolites, (CO)3MnC5H4CO2H and (CO)3MnC5H4CH2OH, which account for 67% and 14% of the urinary tritium, respectively. There metabolites are also excreted in significant quantities in bile, but undergo reabsorption and excretion by the kidney since only a small fraction of the administered tritium appears in the feces. In vitro MMT was rapidly metabolized by a cytochrome P-450-dependent process inducible in liver but not in lung microsomes. In vivo induction by phenobarbital doubles the rate of biliary excretion of MMT metabolites and confers a remarkable protection against the toxic effect of MMT.
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