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  • Title: Studies of circulation and acid-base balance in pregnant sheep: I. The effect of aminophylline infusion.
    Author: Ayromlooi J, Tobias M, Desiderio D.
    Journal: Int J Gynaecol Obstet; 1980; 18(3):218-23. PubMed ID: 6109660.
    Abstract:
    The maternal and fetal effects of aminophylline on hemodynamics and acid-base and blood gas balances were evaluated by 11 infusions to four chronically catheterized sheep at 114-142 days' gestation. Maternal and fetal arterial blood samples were drawn for baseline determination at 15-minute intervals. Mean maternal and fetal pH levels and heart rates increased significantly. Respiratory alkalosis was indicated by a concomitant fall in mean maternal carbon dioxide pressure. We conclude that aminophylline infusion (5.6 mg/kg of body weight/15 min) to pregnant sheep may cause maternal and fetal tachycardia and alkalosis, with a possible increase in uterine blood flow, but no changes in fetal blood gas status or blood pressure.
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