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Title: Rate constants for drug release from micellar solutions of non-ionic surfactants. Author: Collett JH, Dickinson NA. Journal: J Pharm Pharmacol; 1980 Dec; 32(12):805-9. PubMed ID: 6110741. Abstract: The release of weak acid from micellar solutions containing different concentrations of two structurally related non-ionic surfactants was estimated using a dynamic dialysis apparatus. In all cases the effect of the surfactant was to reduce the amount of weak acid transferred. The data have been subjected to compartmental analysis using non-linear regression analysis. Rate constants for exchange cross the dialysis membrane were independent of surfactant concentration. As surfactant concentration increased the rate constants for transfer from the non-micellar region did not show a marked change.[Abstract] [Full Text] [Related] [New Search]