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  • Title: Methylphenidate-like stimulants in vitro release [3H]tyramines but not [14C]dopamine.
    Author: Dyck LE.
    Journal: Eur J Pharmacol; 1981 Jan 29; 69(3):371-4. PubMed ID: 6111462.
    Abstract:
    The effects of methylphenidate, cocaine, nomifensine and amfonelic acid on the simultaneous uptake and release of [14C]dopamine and [3H]p-tyramine or [3H]m-tyramine were examined in rat striatal slices. While the uptake of each amine was inhibited equally by each drug, only [3H]tyramines were released. The d-amphetamine-induced release of [14C]dopamine and [3H]p-tyramine was antagonized by these drugs. These findings suggest that the tyramines can be transported independently from dopamine.
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