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  • Title: Solubilization of neuroleptic/dopamine receptors of human brain striatum.
    Author: Davis A, Madras B, Seeman P.
    Journal: Eur J Pharmacol; 1981 Mar 26; 70(3):321-9. PubMed ID: 6112153.
    Abstract:
    Dopaminergic neuroleptic receptors were solubilized by digitonin from post-mortem human brain putamen. The receptors were labelled by [3H]spiperone and separated from free [3H]spiperone by sephadex chromatography. Neuroleptics and neurotransmitters had similar inhibitory and stereoselective potencies on the solubilized and intact membrane receptors. The KD for [3H]spiperone was apparently high for the solubilized receptors. Unlike the rat striatum, therefore, the human putamen can be solubilized to release neuroleptic/dopamine receptors, permitting the future development of highly sensitive methods for detecting dopamine receptors.
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