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  • Title: Esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol with antiarrhythmic, local anesthetic and other activities.
    Author: Bondavalli F, Longobardi M, Ranise A, Schenone P, Quartuccio A, Ariello B, Perna D, Marmo E.
    Journal: Farmaco Sci; 1981 Feb; 36(2):81-93. PubMed ID: 6112159.
    Abstract:
    A series of aliphatic and aromatic esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol is described. A number of these compounds showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice. Circulatory, cardiac and respiratory effects in dogs are also described.
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