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  • Title: The effect of oral contraceptives on serum lipids gamma-glutamyl transpeptidase, and excretion of d-glucaric acid.
    Author: Hajós P, Berlin I, Intödy Z, Tornyossy M, Káldor A.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1981 Mar; 19(3):117-23. PubMed ID: 6112206.
    Abstract:
    The authors studied three oral contraceptives (Bisecurin, Ovidon, Rigevidon) in 37 healthy women in order to establish their effect on serum lipids, gamma-glutamyl transpeptidase and d-glucaric acid excretion. After 3-9 months of oral contraception, a significant increase was observed in serum cholesterol and beta-lipoprotein levels in women taking the two contraceptives with major hormone content. None of the contraceptives changed the serum glyceride level. Serum gamma-glutamyl transpeptidase levels were significantly enhanced. D-glucaric acid excretion increased. There was no correlation between the parameters of enzyme induction and the change of lipid metabolism.
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