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  • Title: Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole.
    Author: Datta N, Richards H, Datta C.
    Journal: Lancet; 1981 May 30; 1(8231):1181-3. PubMed ID: 6112529.
    Abstract:
    Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.
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