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  • Title: [Membranes properties of granulocytes in Job's-Syndrome with E. coli-septicemia (author's transl)].
    Author: Burdach SE, Rister M, Evers KG.
    Journal: Monatsschr Kinderheilkd; 1981 Apr; 129(4):229-32. PubMed ID: 6112694.
    Abstract:
    Since the age of nine weeks a red haired girl suffered from purulent dermatitis and recurrent, systemic E. coli infections. She had an excessive hyperimmunoglobulinemia E, as well as impaired granulocyte adherence and chemotaxis. Though a sepsis was evident, the granulocytes exhibited a random FITC-Concanavalin A fluorescence. In spite of intensive treatment with various antibiotics and several granulocyte transfusions the child died at the age of 2 years and 11 months. As shown by the FITC-Concanavalin A distribution, the hyperimmunoglobulinemia E may have caused a decreased membrane fluidity causing the impaired adherence and chemotaxis. This could explain the pathophysiology of the Job's Syndrome.
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