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  • Title: Light and electron microscopic localization of enkephalin and tyrosine hydroxylase in neostriatum of fetal and adult rat brain.
    Author: Pickel VM, Beckley SC, Sumal KK, Joh TH, Reis DJ, Miller RJ.
    Journal: Acta Histochem Suppl; 1981; 24():97-105. PubMed ID: 6112776.
    Abstract:
    In fetal rat brain, immunocytochemical localization of tyrosine hydroxylase and methionine (Met5)-enkephalin demonstrates that dopaminergic axons labeled with the biosynthetic enzyme can be detected in th neostriatum prior to the appearance of the peptide in neuronal perikarya. The tyrosine hydroxylase-labeled axon terminals in adult neotriatum may form axodendritio synapses with neurons containing enkephalin. However the majority of the dopaminergic axon terminals lack synaptic specializations in the mature neostriatum.
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