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  • Title: High pressure liquid chromatographic determination of antihistamine-adrenergic combination products: collaborative study.
    Author: Bachman WJ, Alpert MY, Bargo E, Draper RE, Hock WH, Illuminati J, Lookabaugh M, Margosis M, Thompson DW.
    Journal: J Assoc Off Anal Chem; 1981 May; 64(3):564-9. PubMed ID: 6113232.
    Abstract:
    A reverse phase high pressure liquid chromatographic method in which ion-pairing is used for the determination of combinations of pseudoephedrine hydrochloride with triprolidine hydrochloride or chlorpheniramine maleate in syrups and tablets was collaboratively studied by 8 laboratories. Collaborators were supplied with 12 samples including synthetic and commercial syrup formulations and commercial tablet composites. Mean recoveries of pseudoephedrine hydrochloride and triprolidine hydrochloride from synthetic syrup formulations were 100.5 and 99.6%, respectively. Mean recoveries of pseudoephedrine hydrochloride and chlorpheniramine maleate from synthetic syrups were 98.8 and 100.5%, respectively. Mean coefficients of variation for syrups and tablets ranged from 1.68 to 3.07% for pseudoephedrine hydrochloride, from 2.92 to 3.85% for triprolidine hydrochloride, and from 1.34 to 2.15% for chlorpheniramine maleate. The method has been adopted official first action.
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