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  • Title: Calcium transients recorded with arsenazo III in the presynaptic terminal of the squid giant synapse.
    Author: Miledi R, Parker I.
    Journal: Proc R Soc Lond B Biol Sci; 1981 May 22; 212(1187):197-211. PubMed ID: 6113595.
    Abstract:
    Transient changes in free intracellular Ca2+ concentration were monitored in the presynaptic terminal of the giant synapse of the squid, by means of the Ca2+-sensitive dye arsenazo III. Calibration experiments showed a linear relation between the amount of Ca2+ injected by iontophoresis into the terminal, and the peak size of the arsenazo light absorbance record. A light signal could be detected on tetanic stimulation of the presynaptic axon bathed in sea water containing 45 mM Ca2+. During a 1 s tetanus the light signal rose approximately linearly, even though transmitter release declined rapidly and the light signal subsequently declined with a half-time of 2-6 s. The Ca2+ transient elicited by single nerve impulses was recorded by signal averaging, and showed a time course very much slower than the duration of transmitter release.
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